Clinical presentation, treatment, and outcomes of patients with central nervous system involvement in extranodal natural killer/T-cell lymphoma Journal Article
| Authors: | Nevel, K. S.; Pentsova, E.; Daras, M. |
| Article Title: | Clinical presentation, treatment, and outcomes of patients with central nervous system involvement in extranodal natural killer/T-cell lymphoma |
| Abstract: | Extranodal natural killer (NK)/T-cell lymphoma (ENKTCL) is a rare type of Non-Hodgkin’s lymphoma which rarely metastasizes to the central nervous system (CNS). Ten of 60 patients (16.7%) with ENKTCL followed at Memorial Sloan Kettering Cancer Center (MSKCC) were diagnosed with CNS involvement between 1995 and 2016. Eight patients had systemic disease at the time of CNS diagnosis; one patient never developed systemic disease and another was in remission at the time of CNS relapse. Median overall survival was 3.8 months; at time of this report 9 patients have died and one who underwent autologous stem cell transplant (ASCT) is alive 27 months after CNS diagnosis. Five patients achieved a complete response in the CNS; one is still alive, one died of systemic disease, and three died of infection. CNS ENKTCL portends a grim prognosis, with no standard treatment. Prospective study on ASCT and immunotherapy in CNS ENKTCL is warranted. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | central nervous system metastasis; leptomeningeal metastasis; central nervous system lymphoma; extranodal natural killer/t-cell lymphoma; natural killer/t-cell lymphoma |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 60 |
| Issue: | 7 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2019-01-01 |
| Start Page: | 1677 |
| End Page: | 1684 |
| Language: | English |
| DOI: | 10.1080/10428194.2018.1551541 |
| PUBMED: | 30648449 |
| PROVIDER: | scopus |
| PMCID: | PMC7580871 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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