Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: An ex vivo study Journal Article

   


Authors: Iftimia, N.; Peterson, G.; Chang, E. W.; Maguluri, G.; Fox, W.; Rajadhyaksha, M.
Article Title: Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: An ex vivo study
Abstract: We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼1 μm, OCT imaging delineates BCC depth spreading (margins) with resolution of ∼7 μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600 μm, and agreement with histology was within about ±50 μm. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).
Keywords: reflectance confocal microscopy; basal cell carcinoma; confocal microscopy; optical tomography; tomography; ex-vivo; reflectance confocal microscopies; reflection; skin cancers; optical coherence tomography; skin cancer margins delineation; lateral spreading; oct imaging; optical layouts
Journal Title: Journal of Biomedical Optics
Volume: 21
Issue: 1
ISSN: 1083-3668
Publisher: SPIE  
Date Published: 2016-01-18
Start Page: 016006
Language: English
DOI: 10.1117/1.jbo.21.1.016006
PROVIDER: scopus
PMCID: PMC4719216
PUBMED: 26780224
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84955510798&partnerID=40&md5=d793d1da85a506949e4f061dc96cc29b
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Milind Rajadhyaksha
    222 Rajadhyaksha
  2. Gary Peterson
    29 Peterson
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