Handheld optical coherence tomography-reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins Journal Article

   

Authors:	Iftimia, N.; Yélamos, O.; Chen, C. S. J.; Maguluri, G.; Cordova, M. A.; Sahu, A.; Park, J.; Fox, W.; Alessi-Fox, C.; Rajadhyaksha, M.
Article Title:	Handheld optical coherence tomography-reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins
Abstract:	We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo. A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and depth of the BCC tumor and surrounding skin conditions, OCT and RCM imaging are able to complement each other, the strengths of each helping overcome the limitations of the other. Four representative cases are summarized, out of the 15 investigated in a preliminary pilot study, demonstrating how OCT and RCM imaging may be synergistically combined to more accurately detect BCCs and more completely delineate margins. Our preliminary results highlight the potential benefits of combining the two technologies within a single probe to potentially guide diagnosis as well as treatment of BCCs. © 2017 The Authors.
Keywords:	reflectance confocal microscopy; basal cell carcinoma; confocal microscopy; optical tomography; tomography; tumors; diagnosis; probes; representative case; reflectance confocal microscopies; reflection; numerical aperture; skin cancers; optical coherence tomography; potential benefits; skin cancer margins delineation; cross-sectional oct images; human skin in vivo
Journal Title:	Journal of Biomedical Optics
Volume:	22
Issue:	7
ISSN:	1083-3668
Publisher:	SPIE
Date Published:	2017-07-01
Start Page:	076006
Language:	English
DOI:	10.1117/1.jbo.22.7.076006
PROVIDER:	scopus
PUBMED:	28697233
PMCID:	PMC5995139
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85024501573&doi=10.1117%2f1.JBO.22.7.076006&partnerID=40&md5=9b5bc69357db49bd64f07d09ac6c5e17
Notes:	Article -- Export Date: 2 August 2017 -- Source: Scopus

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