Cancer drug development with the help of radiopharmaceuticals: Academic experience Journal Article
| Author: | Larson, S. M. |
| Article Title: | Cancer drug development with the help of radiopharmaceuticals: Academic experience |
| Abstract: | In the last decade radiotracers have been gradually growing in importance as aids for the development of new drugs. This development has been most pronounced for Psychiatric and Neurologic drugs [1, 2], but has more recently been adapted to the development of drugs against cancer. In this mini-review, we describe how advances in molecular imaging of cancer are likely to lead to advances in development and improved application of anti-cancer drugs [3]. We will focus on 4 aspects of use of radiotracers: 1) for treatment response assessment; 2) for the study of kinetics and pharmacology of novel drugs, including bioavailability and local tumor concentration; 3) the identification of the biologic target at the cellular level; 4) the combination of nanocarriers and radioisotopes to improve biodistribution. © 2009 Bentham Science Publishers Ltd. |
| Keywords: | treatment response; unclassified drug; clinical trial; review; cytotoxic agent; drug penetration; nonhuman; solid tumor; antineoplastic agents; drug targeting; positron emission tomography; methodology; antineoplastic agent; radiopharmaceuticals; neoplasm; neoplasms; biological marker; animal; animals; ovary cancer; drug structure; molecular imaging; protein tyrosine kinase; drug design; kidney carcinoma; drug delivery systems; chemistry; drug research; monoclonal antibody g250; drug distribution; isotope labeling; fluorodeoxyglucose f 18; radiopharmaceutical agent; scintiscanning; nanoparticles; nanoparticle; drug monitoring; drug bioavailability; drug metabolism; radioisotope; clear cell carcinoma; folic acid antagonist; single photon emission computer tomography; indium 111; 3' fluorothymidine f 18; radioisotopes; drug tumor level; quinazoline derivative; drug delivery system; drug carrier; dasatinib f 18; monoclonal antibody morab 003; nanocarrier; bioavailability; biological availability; drug carriers |
| Journal Title: | Current Pharmaceutical Design |
| Volume: | 15 |
| Issue: | 9 |
| ISSN: | 1381-6128 |
| Publisher: | Bentham Science Publishers |
| Date Published: | 2009-01-01 |
| Start Page: | 950 |
| End Page: | 956 |
| Language: | English |
| DOI: | 10.2174/138161209787581959 |
| PUBMED: | 19275659 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: CPDEF" - "Source: Scopus" |
