Reprint of: Fast cars and no brakes: Autologous stem cell transplantation as a platform for novel immunotherapies Journal Article
| Authors: | Perales, M. A.; Sauter, C. S.; Armand, P. |
| Article Title: | Reprint of: Fast cars and no brakes: Autologous stem cell transplantation as a platform for novel immunotherapies |
| Abstract: | Autologous stem cell transplantation (ASCT) is indicated in a number of hematologic malignancies, including multiple myeloma, non-Hodgkin lymphoma, and Hodgkin lymphoma. Relapse, however, remains 1 of the main causes of post-ASCT failure, and several strategies are being investigated to decrease the risk of relapse of progression. Recent advances in the treatment of hematological malignancies have included adoptive transfer of genetically modified T cells that express chimeric antigen receptors or T cell receptors, as well the use of checkpoint inhibitors. Early clinical results in nontransplantation patients have been very promising. This review will focus on the use of gene-modified T cells and checkpoint inhibitors in stem cell transplantation. © 2016. |
| Keywords: | autologous stem cell transplantation; immunotherapy; lymphoma; adoptive cell therapy; myeloma; checkpoint inhibitors |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 22 |
| Issue: | 3 Suppl. |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-03-01 |
| Start Page: | S9 |
| End Page: | S14 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2016.01.005 |
| PROVIDER: | scopus |
| PUBMED: | 26899275 |
| DOI/URL: | |
| Notes: | Review -- Presented as an educational/critical review at: 2016 BMT Tandem Meetings; 2016 Feb 18-22; Honolulu, Hawaii -- Export Date: 3 March 2016 -- Source: Scopus |
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