Fast cars and no brakes: Autologous stem cell transplantation as a platform for novel immunotherapies Journal Article
| Authors: | Perales, M. A.; Sauter, C. S.; Armand, P. |
| Article Title: | Fast cars and no brakes: Autologous stem cell transplantation as a platform for novel immunotherapies |
| Abstract: | Autologous stem cell transplantation (ASCT) is indicated in a number of hematologic malignancies, including multiple myeloma, non-Hodgkin lymphoma, and Hodgkin lymphoma. Relapse, however, remains 1 of the main causes of post-ASCT failure, and several strategies are being investigated to decrease the risk of relapse of progression. Recent advances in the treatment of hematological malignancies have included adoptive transfer of genetically modified T cells that express chimeric antigen receptors or T cell receptors, as well the use of checkpoint inhibitors. Early clinical results in nontransplantation patients have been very promising. This review will focus on the use of gene-modified T cells and checkpoint inhibitors in stem cell transplantation. © 2016 American Society for Blood and Marrow Transplantation. |
| Keywords: | allogeneic stem cell transplantation; review; cancer recurrence; cancer immunotherapy; multiple myeloma; autologous stem cell transplantation; tumor antigen; hodgkin disease; t lymphocyte receptor; nonhodgkin lymphoma; dna modification; immunotherapy; lymphoma; adoptive cell therapy; chimeric antigen receptor; adoptive transfer; myeloma; human; checkpoint inhibitors |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 22 |
| Issue: | 1 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-01-01 |
| Start Page: | 17 |
| End Page: | 22 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2015.10.014 |
| PROVIDER: | scopus |
| PMCID: | PMC4706480 |
| PUBMED: | 26485445 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 February 2016 -- Source: Scopus |
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