Stop and go: Hematopoietic cell transplantation in the era of chimeric antigen receptor T cells and checkpoint inhibitors Journal Article

Authors: Ghosh, A.; Politikos, I.; Perales, M. A.
Article Title: Stop and go: Hematopoietic cell transplantation in the era of chimeric antigen receptor T cells and checkpoint inhibitors
Abstract: Purpose of review: For several decades, hematopoietic cell transplantation (HCT) has been considered the standard curative therapy for many patients with hematological malignancies. In addition to the cytotoxic effects of the chemotherapy and radiation used in the conditioning regimen, the benefits of HCT are derived from a reset of the immune system and harnessing the ability of donor T cells to eliminate malignant cells. With the dawn of the era of immunotherapies in the form of checkpoint inhibitors and chimeric antigen receptor (CAR) T cells, the role of HCT has evolved. Recent findings: Immunotherapy with checkpoint inhibitors is increasingly being used for relapsed Hodgkin and non-Hodgkin lymphoma after autologous HCT. Checkpoint inhibitors are also being tested after allogeneic HCT with observable benefits in treating hematological malignancies, but with a potential risk of increased graft versus host disease and transplant-related mortality. Immunotherapy with Cluster of differentiation 19 CAR T cells are powerful options with aggressive B-cell malignancies both for therapy and as induction leading to allogeneic HCT. Summary: Although immunotherapies with checkpoint inhibition and CAR T cells are increasingly being used to treat hematological malignancies, HCT remains a standard of care for most of the diseases with the best chance of cure. Combination of these therapies with HCT has the potential to more effectively treat hematological malignancies. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: immunotherapy; hematopoietic cell transplantation; checkpoint blockade; chimeric antigen receptors
Journal Title: Current Opinion in Oncology
Volume: 29
Issue: 6
ISSN: 1040-8746
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-11-01
Start Page: 474
End Page: 483
Language: English
DOI: 10.1097/cco.0000000000000408
PROVIDER: scopus
PUBMED: 28872470
PMCID: PMC5806704
Notes: Review -- Export Date: 2 November 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Miguel-Angel Perales
    494 Perales
  2. Arnab Ghosh
    49 Ghosh