Immunotherapy of lymphoma and myeloma: Facts and hopes Journal Article

Authors: Pianko, M. J.; Moskowitz, A. J.; Lesokhin, A. M.
Article Title: Immunotherapy of lymphoma and myeloma: Facts and hopes
Abstract: Immune checkpoint blockade has driven a revolution in modern oncology, and robust drug development of immune checkpoint inhibitors is underway in both solid tumors and hematologic malignancies. High response rates to programmed cell death 1 (PD-1) blockade using nivolumab or pembrolizumab in classical Hodgkin lymphoma (cHL) and several variants of non-Hodgkin lymphoma (NHL) revealed an intrinsic biological sensitivity to this approach, and work is ongoing exploring combinations with immune checkpoint inhibitors in both cHL and NHL. There are also preliminary data suggesting antitumor efficacy of PD-1 inhibitors used in combination with immunomodulatory drugs in multiple myeloma, and effects of novel monoclonal antibody therapies on the tumor microenvironment may lead to synergy with checkpoint blockade. Although immune checkpoint inhibitors are generally well tolerated, clinicians must use caution and remain vigilant when treating patients with these agents in order to identify immune-related toxicities and prevent treatment-related morbidity and mortality. Autologous stem cell transplant is a useful tool for treatment of hematologic malignancies and has potential as a platform for use of immune checkpoint inhibitors. An important safety signal has emerged surrounding the risk of graft-versus-host disease associated with use of PD-1 inhibitors before and after allogeneic stem cell transplant. We aim to discuss the facts known to date in the use of immune checkpoint inhibitors for patients with lymphoid malignancies and our hopes for expanding the benefits of immunotherapy to patients in the future. © 2017 American Association for Cancer Research.
Keywords: signal transduction; protein expression; review; doxorubicin; drug efficacy; drug safety; gene overexpression; carboplatin; dacarbazine; cancer immunotherapy; etoposide; bendamustine; ifosfamide; vinblastine; hodgkin disease; regulatory t lymphocyte; antigen specificity; lymphoma; bleomycin; immunomodulation; monoclonal immunoglobulinemia; autologous hematopoietic stem cell transplantation; myeloma; tumor microenvironment; copy number variation; brentuximab vedotin; nivolumab; human; priority journal; pembrolizumab
Journal Title: Clinical Cancer Research
Volume: 24
Issue: 5
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2018-03-01
Start Page: 1002
End Page: 1010
Language: English
DOI: 10.1158/1078-0432.ccr-17-0539
PROVIDER: scopus
PMCID: PMC5844779
PUBMED: 28899972
Notes: Review -- Export Date: 2 July 2018 -- Source: Scopus
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MSK Authors
  1. Alison Moskowitz
    140 Moskowitz
  2. Alexander Meyer Lesokhin
    114 Lesokhin
  3. Matthew James Pianko
    4 Pianko