Clinical development of PD-1 blockade in hematologic malignancies Journal Article


Authors: Pianko, M. J.; Goldberg, A. D.; Lesokhin, A. M.
Article Title: Clinical development of PD-1 blockade in hematologic malignancies
Abstract: Clinical development of immune checkpoint inhibitors targeting the PD-1 pathway has led to clinical benefits for patients with multiple solid tumor and hematologic malignancies and has revolutionized modern oncology. High response rates to PD-1 blockade in patients with classical Hodgkin lymphoma and certain subtypes of non-Hodgkin lymphoma highlight an intrinsic biologic sensitivity to this strategy of treatment. Despite early success of checkpoint inhibitor and immunomodulatory drug combinations in phase 2 studies in multiple myeloma, safety concerns in patients treated with the combination of immunomodulatory drugs and checkpoint inhibitors in myeloma have stalled drug development in this space. Novel combination approaches exploring PD-1 inhibitors with epigenetic modifiers in leukemia are underway. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: leukemia; unclassified drug; review; unspecified side effect; antineoplastic agent; biological marker; cancer immunotherapy; multiple myeloma; cancer regression; hematologic malignancy; nonhodgkin lymphoma; immune response; lymphoma; hematologic malignancies; myeloma; classical hodgkin lymphoma; programmed death 1 ligand 1; programmed death 1 receptor; molecularly targeted therapy; human; priority journal; programmed death 1 ligand 2; immune checkpoint inhibitors; programmed death 1 receptor inhibitor
Journal Title: The Cancer Journal
Volume: 24
Issue: 1
ISSN: 1528-9117
Publisher: Lippincott Williams & Wilkins  
Date Published: 2018-01-01
Start Page: 31
End Page: 35
Language: English
DOI: 10.1097/ppo.0000000000000297
PROVIDER: scopus
PMCID: PMC5785103
PUBMED: 29360725
DOI/URL:
Notes: Review -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. Alexander Meyer Lesokhin
    115 Lesokhin
  2. Matthew James Pianko
    4 Pianko