Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells Journal Article
| Authors: | Muñoz-Descalzo, S.; Hadjantonakis, A. K.; Arias, A. M. |
| Article Title: | Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells |
| Abstract: | Wnt/ß-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ß-catenin: it promotes differentiation when activated as part of the Wnt/ß-catenin signalling pathway, and promotes stable pluripotency independently of signalling. Although mES cells resemble the preimplantation epiblast progenitors, the first requirement for Wnt/ß-catenin signalling during mouse development has been reported at implantation [1,2]. The relationship between ß-catenin and pluripotency and that of mES cells with epiblast progenitors suggests that ß-catenin might have a functional role during preimplantation development. Here we summarize the expression and function of Wnt/ß-catenin signalling elements during the early stages of mouse development and consider the reasons why the requirement in ES cells do not reflect the embryo. © 2015 . |
| Keywords: | review; nonhuman; animal cell; mouse; embryo; transcription factor; embryo development; cell differentiation; stem cells; beta catenin; wnt protein; embryogenesis; ectoderm; signalling; primordium; wnt signaling pathway; blastoma; wnt signalling; information processing device; mouse embryonic stem cell |
| Journal Title: | Seminars in Cell and Developmental Biology |
| Volume: | 47-48 |
| ISSN: | 1084-9521 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-12-01 |
| Start Page: | 101 |
| End Page: | 109 |
| Language: | English |
| DOI: | 10.1016/j.semcdb.2015.08.011 |
| PROVIDER: | scopus |
| PUBMED: | 26321498 |
| PMCID: | PMC4955857 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 February 2016 -- Source: Scopus |
