Role of canonical Wnt signaling/β-catenin via Dermo1 in cranial dermal cell development Journal Article
| Authors: | Tran, T. H.; Jarrell, A.; Zentner, G. E.; Welsh, A.; Brownell, I.; Scacheri, P. C.; Atit, R. |
| Article Title: | Role of canonical Wnt signaling/β-catenin via Dermo1 in cranial dermal cell development |
| Abstract: | Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, we show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. We show that Wnt signaling/β-catenin is absolutely required and sufficient for Dermo1 expression and dermal cell identity in the cranium. The absence of the Wnt signaling cue leads to formation of cartilage in craniofacial and ventral trunk regions at the expense of dermal and bone lineages. Dermo1 can be a direct transcription target and may mediate the functional role of Wnt signaling in dermal precursors. This study reveals a lineage-specific role of canonical Wnt signaling/β-catenin in promoting dermal cell fate in distinct precursor populations. |
| Keywords: | signal transduction; controlled study; unclassified drug; nonhuman; biological markers; animal cell; mouse; animals; mice; animal tissue; protein; protein binding; cell fate; cell differentiation; homeodomain proteins; dermis; cell lineage; stem cell; molecular sequence data; brain development; stem cells; base sequence; embryo, mammalian; wnt proteins; beta catenin; nerve cell differentiation; repressor proteins; mesoderm; body patterning; skin cell; intracellular signaling; enhancer elements, genetic; basic helix-loop-helix leucine zipper transcription factors; skull; twist transcription factor; cartilage; trunk; sox9 transcription factor; cranial bone; cranial dermis; craniofacial; protein dermo1; canonical analysis |
| Journal Title: | Development |
| Volume: | 137 |
| Issue: | 23 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2010-12-01 |
| Start Page: | 3973 |
| End Page: | 3984 |
| Language: | English |
| DOI: | 10.1242/dev.056473 |
| PUBMED: | 20980404 |
| PROVIDER: | scopus |
| PMCID: | PMC2976281 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: DEVPE" - "Source: Scopus" |
