Single cells get together: High-resolution approaches to study the dynamics of early mouse development Journal Article
| Authors: | Saiz, N.; Plusa, B.; Hadjantonakis, A. K. |
| Article Title: | Single cells get together: High-resolution approaches to study the dynamics of early mouse development |
| Abstract: | Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are making it possible to study cellular populations at single-cell resolution and begin to integrate different inputs, for example genetic, physical and chemical factors, that affect cell differentiation over spatial and temporal scales. The preimplantation mouse embryo allows the analysis of cell fate decisions in vivo with high spatiotemporal resolution. In this review we highlight how the application of live imaging and single-cell resolution analysis pipelines is providing an unprecedented level of insight on the processes that shape the earliest stages of mammalian development. © 2015 Elsevier Ltd. |
| Keywords: | review; nonhuman; cell fate; embryo development; cell differentiation; messenger rna; genomics; cell interaction; transcriptome; preimplantation embryo; systems biology; mouse embryo; blastocyst; rna sequence; single cell analysis; single-cell analysis; lineage specification; quantitative high-resolution imaging |
| Journal Title: | Seminars in Cell and Developmental Biology |
| Volume: | 47-48 |
| ISSN: | 1084-9521 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-12-01 |
| Start Page: | 92 |
| End Page: | 100 |
| Language: | English |
| DOI: | 10.1016/j.semcdb.2015.06.004 |
| PROVIDER: | scopus |
| PMCID: | PMC4688173 |
| PUBMED: | 26183190 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 February 2016 -- Source: Scopus |
