Regulation of human drug metabolism by dietary factors Conference Paper


Authors: Conney, A. H.; Buening, M. K.; Pantuck, E. J.; Pantuck, C. B.; Fortner, J. G.; Anderson, K. E.; Kappas, A.
Title: Regulation of human drug metabolism by dietary factors
Conference Title: Symposium on Drug-Metabolizing Enzymes and Environmental Chemicals: Toxic Interactions
Abstract: Several dietary factors influence the oxidative metabolism of chemicals in humans. Increasing the ratio of protein to carbohydrate or fat in the diet, feeding cabbage and brussels sprouts or feeding charcoal-broiled beef for several days stimulates human drug metabolism. The chronic ingestion of ethanol stimulates drug metabolism whereas the chronic ingestion of methylxanthine-containing foods inhibits drug metabolism. In contrast, an increase in the ratio of fat to carbohydrate in the diet of normal subjects or the fasting of obese individuals for several days has little or no effect on drug metabolism. Flavonoids in edible plants influence the metabolism of foreign chemicals by human liver in vitro. The addition of flavone, tangeretin or nobiletin to human liver microsomes activates both the hydroxylation of benzo[a]pyrene and the metabolism of aflatoxin B1 to mutagens. On the other hand, quercetin, kaempferol, morin and chrysin, which are also normally occurring flavonoids, inhibit the hydroxylation of benzo[a]pyrene by human liver microsomes. © Excerpta Medica 1980.
Keywords: hydroxylation; chemicals; chronic ingestion; human drug metabolism; human liver mocrosomes
Journal Title Ciba Foundation Symposia
Volume: 76
Conference Dates: 1979 Oct 23-25
Conference Location: London, United Kingdom
ISBN: 0300-5208
Publisher: John Wiley & Sons  
Date Published: 1980-01-01
Start Page: 147
End Page: 162; discussion 162-168
Language: English
DOI: 10.1002/9780470720592.ch9
PROVIDER: scopus
PUBMED: 6906262
DOI/URL:
Notes: "Environmental Chemicals, Enzyme Function and Human Disease" (ISBN: 0-444-90157-4) -- Export Date: 3 February 2016 -- Book Chapter -- Source: Scopus
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  1. Joseph G Fortner
    30 Fortner