12-O-tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells Journal Article


Author: Higgins, P. J.
Article Title: 12-O-tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells
Abstract: Established RLC-1 adult rat liver endothelial cells were utilized to assess promotional requirements of hepatic endothelial elements to malignant transformation following in vitro exposure to carcinogens requiring metabolic activation. Diethylnitrosamine failed to transform RLC-1 cells with or without tetradecanoylphorbol acetate (TPA) promotion. Benzo(a)pyrene was previously shown to initiate certain growth changes in the RLC-1 line; these cells, however, required TPA promotion prior to expression of the fully transformed phenotype.
Keywords: in vitro study; carcinogenesis; endothelium cell; liver; cell culture; cell transformation; rat; benzo[a]pyrene; tumor promoter; phorbol 13 acetate 12 myristate; priority journal; diethylnitrosamine
Journal Title: Oncology
Volume: 42
Issue: 5
ISSN: 0030-2414
Publisher: S. Karger AG  
Date Published: 1985-01-01
Start Page: 301
End Page: 303
Language: English
DOI: 10.1159/000226050
PROVIDER: scopus
PUBMED: 4034145
DOI/URL:
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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  1. Paul J. Higgins
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