Metabolism of perylene by monooxygenases of the skin and liver of Ambystoma tigrinum Journal Article
| Authors: | Anderson, R. S.; Angel, M. A.; Rose, F. L. |
| Article Title: | Metabolism of perylene by monooxygenases of the skin and liver of Ambystoma tigrinum |
| Abstract: | The prevalence of dermal neoplasia among neotenic tiger salamanders (Ambystoma tigrinum) collected from the Reese Air Force Base sewage lagoon far exceeded that among salamanders from nearby uncontaminated lagoons. Perylene was the predominant pglycyclic aromatic hydrocarbon contaminant in this lagoon. Perylene was shown to be a substrate for monooxygenases in skin and liver homogenates and formed DNA-binding metabolites. Perylene exposure appeared to augment subsequent perylene metabolism by dermal enzymes but it was not a strong inducer of hepatic monooxygenases. Aroclor 1254 induced benzo(a)pyrene and perylene metabolism by both skin and liver enzymes. However, perylene apparently was not activated by salamander enzymes, as suggested by its lack of in vitro mutagenicity and failure to induce tumors. © 1988. |
| Keywords: | nonhuman; animal experiment; liver enzyme; unspecific monooxygenase; amphibia; perylene; ambystoma tigrinum; lagoon; sewage; skin enzyme |
| Journal Title: | Marine Environmental Research |
| Volume: | 24 |
| Issue: | 1-4 |
| ISSN: | 0141-1136 |
| Publisher: | Elsevier Ltd |
| Date Published: | 1988-01-01 |
| Start Page: | 79 |
| End Page: | 83 |
| Language: | English |
| DOI: | 10.1016/0141-1136(88)90258-9 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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