Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia Journal Article


Authors: Heerema, N. A.; Sather, H. N.; Sensel, M. G.; Lee, M. K.; Hutchinson, R. J.; Nachman, J. B.; Reaman, G. H.; Lange, B. J.; Steinherz, P. G.; Bostrom, B. C.; Gaynon, P. S.; Uckun, F. M.
Article Title: Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia
Abstract: Purpose: Little is known about nonrandom deletions of chromosome bands 13q12 to 13q14 (13q12-14) in acute lymphoblastic leukemia (ALL), We determined the prognostic significance of cytogenetically identified breakpoints in 13q12-14 in children with newly diagnosed ALL treated on Children's Cancer Group protocols from 1988 to 1995. Patients and Methods: Breakpoint in 13q12-14 were identified in 36 (2%) of the 1,946 cases with accepted cytogenetic data. Outcome analysis used standard life-table methods. Results: Seventeen patients (47%) with an abnormal 13q12-14 were classified, according to the National Cancer Institute (NCI), as poor risk, and 15 patients (42%) were standard risk; four(11%)were infants less than 12 months of age. Eight cases had balanced rearrangements of 13q12-14, 27 patients had a partial loss of 13q, and one held both ct partial gain and a partial loss. The most frequent additional abnormalities among these patients were an abnormal 12p, a del(bq), a del(9p), a 14q11 breakpoint, and an 11q23 breakpoint. Nineteen patients were pseudodiploid, 10 were hyperdiploid, and seven were hypodiploid. Patients with an abnormal 13q12-14 had significantly worse event-free survival than patients lacking such an abnormality, with estimates at 6 years of 61% (SD = 14%) and 74% (SD = 1%), respectively (P =.04; relative risk = 1.74), Overall survival, however, was similar for the two groups (P =.25). The prognostic effect of an abnormal 13q was attenuated in a multivariate analysis adjusted for NCI risk status and ploidy IP =.72), Conclusion: Aberrations of 13q12-14 may contribute to leukemogenesis of childhood ALL and confer increased risk of treatment failure but are associated with other poor-risk features. (C) 2000 by American Society of Clinical Oncology.
Keywords: myeloproliferative disorder; gene; translocation; high-risk; features; growth-factor; chronic lymphocytic-leukemia; deletion; receptor-1; childrens cancer group; breakpoint; d13s25 locus
Journal Title: Journal of Clinical Oncology
Volume: 18
Issue: 22
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2000-11-15
Start Page: 3837
End Page: 3844
Language: English
ACCESSION: WOS:000165352300012
PROVIDER: wos
PUBMED: 11078497
Notes: Article -- Source: Wos