| Abstract: |
We have compared outcome for 167 (9.0%) children with a del(6q) and 1713 (91%) children without a del(6q) treated on Children's Cancer Group (CCG) risk-adjusted treatment protocols for acute lymphoblastic leukemia (ALL). Thirty-three patients had a del(6q) as the sole aberration; 22 patients had a del(6q) only as a secondary abnormality. Thirty-six cases had a del(6q) and high hyperdiploidy (> 50 chromosomes). Six patients with a del(6q) also had +16 and 8 patients had loss of a sex chromosome. Frequent recurring breakpoints were q13, q15, q21, q23, and q25. Patients with a del(6q) were more likely to have T-lineage ALL (p < 0.001), a mediastinal mass (p = 0.01), and higher WBC counts (p = 0.04), although only half of these patients were classified as poor risk. Event-free survival at 6 years was similar for patients with or without a del(6q), with estimates of 77% (SD = 5%) and 74% (SD = 2%), respectively (p = 0.44). This finding was also observed within NCI poor and standard risk groups. Thus, cytogenetically detectable del(6q) is not associated with adverse risk in pediatric ALL. |
| Keywords: |
cancer survival; child; child, preschool; disease-free survival; human cell; major clinical study; cancer risk; antineoplastic agents; chromosome; cytogenetics; acute lymphoblastic leukemia; infant; chromosome breakage; chromosomes, human, pair 6; leukocyte count; children; childhood leukemia; chromosome deletion; mediastinum; chromosome loss; t cell leukemia; chromosome 6q; diploidy; deletion; leukemia, lymphocytic, acute, l1; humans; prognosis; human; male; female; priority journal; article; interstitial chromosome deletion; 6q; sex chromosome aberration
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