Molecular cloning of the murine cMOAT ATPase Journal Article
| Authors: | Fritz, F.; Chen, J.; Hayes, P.; Sirotnak, F. M. |
| Article Title: | Molecular cloning of the murine cMOAT ATPase |
| Abstract: | cMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicular surface of hepatocytes that has pharmacologic significance. We describe here the cloning of a murine cMOAT cDNA isolated from mouse liver. The open reading frame of this cDNA incorporates 4627 nucleotides encoding 1309 amino acids with 77.5% and 86.7% identity with the human and rat encoded amino acids, respectively. Northern blotting showed that the expression of cMOAT mRNA occurs primarily in mouse liver in the form of two variants with approximately 5.6 and 7.8 kb of sequence each. cMOAT mRNA was also detected in mouse kidney at a low level but was not detected in other mouse organs or tumors except the Hep 1-6 murine hepatoma where expression was also in the form of the same two mRNA variants. (C) 2000 Elsevier Science B.V. All rights reserved. |
| Keywords: | gene; rats; cancer cell-lines; canalicular multispecific anion transporter; murine cdna; organic anion transporter |
| Journal Title: | Biochimica Et Biophysica Acta (BBA) - Gene Structure and Expression |
| Volume: | 1492 |
| Issue: | 2-3 |
| ISSN: | 0167-4781 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2000-07-24 |
| Start Page: | 531 |
| End Page: | 536 |
| Language: | English |
| ACCESSION: | WOS:000088343300033 |
| DOI: | 10.1016/s0167-4781(00)00132-9 |
| PROVIDER: | wos |
| PUBMED: | 11004524 |
| Notes: | Article -- Source: Wos |
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