Laser-capture microdissected Schwannian and neuroblastic cells in stage 4 neuroblastomas have the same genetic alterations Journal Article
| Authors: | Mora, J.; Akram, M.; Cheung, N. K. V.; Chen, L.; Gerald, W. L. |
| Article Title: | Laser-capture microdissected Schwannian and neuroblastic cells in stage 4 neuroblastomas have the same genetic alterations |
| Abstract: | Background. Neuroblastoma (NB) is a heterogeneous tumor composed of mixed populations of neuroblastic, Schwannian, and gangliocytic cells. Procedure. We examined the genetic lineage of Schwannian and neuroblastic cells in stage 4 NB using laser-capture microdissection (LCM) and allelic analysis of microsatellite markers of chromosomes 1p, 11q, and 14q. Results. In 18 out of 19 cases, individual cell types exhibited the same allelotype. Conclusion. Our results provide evidence that the majority of Schwannian and neuroblastic cells in stage 4 NB are of neoplastic origin, and support the hypothesis of a tumor stem cell capable of development along multiple lineages. (C) 2000 Wiley-Liss, Inc. |
| Keywords: | child; clinical article; human tissue; conference paper; cancer staging; neoplasm staging; allele; cell population; cell lineage; cell type; stem cell; neuroblastoma; lasers; schwann cell; nerve cell; neuroblast; chromosome 11q; chromosome 14q; chromosome 1p; schwann cells; chromosome microdissection; laser-capture microdissection; humans; human; priority journal; neuroblastic cells; chromosome marker |
| Journal Title: | Medical and Pediatric Oncology |
| Volume: | 35 |
| Issue: | 6 |
| ISSN: | 0098-1532 |
| Publisher: | Wiley Liss |
| Date Published: | 2000-12-01 |
| Start Page: | 534 |
| End Page: | 537 |
| Language: | English |
| DOI: | 10.1002/1096-911x(20001201)35:6<534::aid-mpo7>3.0.co;2-r |
| PUBMED: | 11107110 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work