The transcription role of PML and the nuclear body Journal Article
| Authors: | Zhong, S.; Salomoni, P.; Pandolfi, P. P. |
| Article Title: | The transcription role of PML and the nuclear body |
| Abstract: | The PML gene encodes a turnout suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various functions have been attributed to the PML nuclear body, but its main biochemical role is still unclear. Recent findings indicate that PML is essential for the proper formation of the nuclear body and can act as a transcriptional co-factor. Here we summarize the current understanding of the biological functions of PML and the nuclear body, and discuss a role for these intra-nuclear structures in the regulation of transcription. |
| Keywords: | controlled study; review; nonhuman; protein domain; animal cell; animal; animals; nuclear protein; neoplasm proteins; transcription factor; genetic transcription; transcription, genetic; physiology; transcription factors; nuclear proteins; molecular cloning; cancer inhibition; tumor suppressor gene; chemistry; transcription regulation; tumor suppressor proteins; tumor protein; promyelocytic leukemia; cell nucleus; tumor suppressor protein; genetic code; ultrastructure; cell nucleus inclusion body; priority journal |
| Journal Title: | Nature Cell Biology |
| Volume: | 2 |
| Issue: | 5 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2000-05-01 |
| Start Page: | E85 |
| End Page: | E90 |
| Language: | English |
| DOI: | 10.1038/35010583 |
| PUBMED: | 10806494 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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