Physical and functional link of the leukemia-associated factors AML1 and PML Journal Article
| Authors: | Nguyen, L. A.; Pandolfi, P. P.; Aikawa, Y.; Tagata, Y.; Ohki, M.; Kitabayashi, I. |
| Article Title: | Physical and functional link of the leukemia-associated factors AML1 and PML |
| Abstract: | The AML1-CBFbeta transcription factor complex is the most frequent target of specific chromosome translocations in acute myeloid leukemia (AML). The promyelocytic leukemia (PML) gene is also frequently involved in AML-associated translocation. Here we report that a specific isoform PML I forms a complex with AML1. PML I was able to recruit AML1 and coactivator p300 in PML nuclear bodies and enhance the AML1-mediated transcription in the presence of p300. A specific C-terminal region of PML I and a C-terminal region of AML1 were found to be required for both their association and colocalization in the nuclear bodies. Overexpression of PML I stimulates myeloid cells to differentiate. These results suggest that PML I could act as a mediator for AML1 and its coactivator p300/CBP to assemble into functional complexes and, consequently, activate AML1-dependent transcription and myeloid cell differentiation. (C) 2005 by The American Society of Hematology. |
| Keywords: | transcription factors; hematopoiesis; fetal liver; acute promyelocytic leukemia; acute myeloid-leukemia; acute; lymphoblastic-leukemia; core-binding-factor; dna-binding; multiple chromosomal translocations; activate; stimulating factor-receptor; synergistically |
| Journal Title: | Blood |
| Volume: | 105 |
| Issue: | 1 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2005-01-01 |
| Start Page: | 292 |
| End Page: | 300 |
| Language: | English |
| DOI: | 10.1182/blood-2004-03-1185 |
| ACCESSION: | WOS:000225997100050 |
| PROVIDER: | wos |
| PUBMED: | 15331439 |
| Notes: | --- - Article - "Source: Wos" |
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