The puzzling multiple lives of PML and its role in the genesis of cancer Journal Article
| Authors: | Ruggero, D.; Wang, Z. G.; Pandolfi, P. P. |
| Article Title: | The puzzling multiple lives of PML and its role in the genesis of cancer |
| Abstract: | PML, the gene associated with acute promyelocytic leukemia (APL); PML, the target of numerous viral agents; PML, the growth suppressor; PML, the mediator of multiple apoptotic pathways; PML, the tumor suppressor; PML, the protein which epitomizes a novel nuclear structure, the nuclear body; PML, the transcription co-factor. Despite the recent flurry of reports attributing multiple biological roles to the PML protein, PML still lacks a definitive biochemical function. This is probably the reason why PML is so attractive to many investigators. Here, we will summarize the facts and speculations on this puzzling protein. (C) 2000 John Wiley and Sons, Inc. |
| Keywords: | genetics; review; cell division; nuclear protein; neoplasm proteins; transcription factor; cell differentiation; pathology; transcription factors; cell transformation, neoplastic; nuclear proteins; gene expression regulation; leukemia, promyelocytic, acute; gene expression regulation, neoplastic; cell transformation; tumor suppressor proteins; tumor protein; promyelocytic leukemia; tumor suppressor protein; pml protein, human; humans; human |
| Journal Title: | BioEssays |
| Volume: | 22 |
| Issue: | 9 |
| ISSN: | 0265-9247 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2000-09-01 |
| Start Page: | 827 |
| End Page: | 835 |
| Language: | English |
| DOI: | 10.1002/1521-1878(200009)22:9<827::aid-bies8>3.0.co;2-1 |
| PUBMED: | 10944585 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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