Molecular biology of leukemia Journal Article
| Authors: | Jakubowiak, A.; Cammenga, J.; Sokolic, R.; Alvarez, S.; Jackson, G.; Hedvat, C.; Nimer, S. D. |
| Article Title: | Molecular biology of leukemia |
| Abstract: | Identification and characterization of leukemia-related chromosomal translocations have had significant impact on all aspects of the management of acute leukemia, including its diagnosis, assignment of prognosis, and development of an appropriate treatment plan. Several genes are recurrent targets of chromosomal abnormalities, suggesting that they play a key role in leukemogenesis. Significant progress has been made to define potentially unifying molecular mechanisms of leukemic transformation. Hopefully, these findings will provide the basis for molecularly targeted therapies for leukemia. |
| Keywords: | leukemia; genetics; review; methodology; sensitivity and specificity; molecular biology; genetic screening; humans; human; male; female |
| Journal Title: | Current Oncology Reports |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2000-04-01 |
| Start Page: | 123 |
| End Page: | 131 |
| Language: | English |
| PUBMED: | 11122833 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s11912-000-0083-z |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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