Detection of posttransplant minimal disease chronic myelogenous leukemia by bcr rearrangement analysis Journal Article

  

Authors:	Anderson, A. E.; Schneider, N. R.; Allen, G. J.; Ranganathan, R.; Burns, J.; Jhanwar, S. C.; Klein, E. A.; Cunningham, I.; O'Reilly, R. J.; Chaganti, R. S. K.
Article Title:	Detection of posttransplant minimal disease chronic myelogenous leukemia by bcr rearrangement analysis
Abstract:	Until recently, cytogenetic detection of the Philadelphia chromosome (Ph) was the only reliable test to diagnose chronic myelogenous leukemia (CML) and detect minimal disease or early relapse following treatment. However, the recently developed ability to detect the Ph chromosome as a rearrangement in the bcr gene of chromosome 22 permits identification of the leukemic clone comprising as little as 5% of the cell population. We present results of simultaneous cytogenetic and DNA rearrangement studies in 28 CML patients considered for or treated with bone marrow transplantation. Our results show that the molecular method is significantly more sensitive than the cytogenetic method in the detection of minimal disease Ph-positive clones. © 1989.
Keywords:	clinical article; cytology; heredity; recurrence; chronic myeloid leukemia; gene rearrangement; genetic engineering; chromosome translocation; radioisotope; bone marrow transplantation; karyotyping; chromosome 22; philadelphia chromosome; leukemia, myeloid, chronic; prognosis; human; priority journal; support, u.s. gov't, p.h.s.
Journal Title:	Cancer Genetics and Cytogenetics
Volume:	43
Issue:	1
ISSN:	0165-4608
Publisher:	Elsevier Science, Inc.
Date Published:	1989-11-01
Start Page:	67
End Page:	71
Language:	English
DOI:	10.1016/0165-4608(89)90128-3
PUBMED:	2790774
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024464889&doi=10.1016%2f0165-4608%2889%2990128-3&partnerID=40&md5=d6c1bb450a0a02677b4cc63297842ea9
Notes:	Article -- Export Date: 14 April 2020 -- Source: Scopus

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