A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia Journal Article
| Authors: | Yao, J.; Douer, D.; Wang, L.; Arcila, M. E.; Nafa, K.; Chiu, A. |
| Article Title: | A case of acute myeloid leukemia with e6a2 BCR-ABL fusion transcript acquired after progressing from chronic myelomonocytic leukemia |
| Abstract: | Philadelphia (Ph) chromosome is a cytogenetic hallmark of chronic myeloid leukemia (CML). Most patients with CML harbor either the e13a2 or e14a2 BCR-ABL fusion product, while a small subset of the cases expresses e1a2 or e19a2 transcripts. We report a patient with chronic myelomonocytic leukemia (CMML), initially Ph chromosome negative at presentation, with rapid disease progression to acute myeloid leukemia (AML) and appearance of Ph chromosome and BCR-ABL e6a2, a very uncommon fusion transcript. The AML was refractory to treatment with subsequent emergence and dominance of a Ph negative leukemic clone. The patient expired shortly after disease progression. © 2017 The Authors |
| Keywords: | cmml; aml transformation; bcr-abl e6a2 |
| Journal Title: | Leukemia Research Reports |
| Volume: | 7 |
| ISSN: | 2213-0489 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-01-01 |
| Start Page: | 17 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1016/j.lrr.2017.01.003 |
| PROVIDER: | scopus |
| PMCID: | PMC5328719 |
| PUBMED: | 28275539 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 April 2017 -- Source: Scopus |
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