| Abstract: |
Suppression or eradication of the Philadelphia (Ph 1 ) chromosome has been a major goal in the therapy of chronic myelogenous leukemia (CML). Variable levels of Ph 1 chromosome negativity have been achieved using interferon-alfa, busulfan, combination chemotherapy, and allogeneic bone marrow transplantation. This study evaluated the effect of achieving a predetermined level of myelosuppression using hydroxyurea on bone marrow cytogenetics in CML. Fourteen patients with chronic phase CML received 25 cycles of therapy. Fourteen of the 25 cycles were associated with cytogenetic responses consisting of 25% or more Ph 1 negative metaphases (range, 25% to 100%). Nine of the responses consisted of 50% or greater Ph 1 negative metaphases. Toxicity was exclusively due to consequences of myelosuppression, including febrile neutropenia and thrombocytopenia. In chronic phase CML, hydroxyurea induces cytogenetic responses with tolerable toxicity and is an attractive agent for further study as a component of treatment strategies aimed at eradicating the Ph 1 + population in CML. © 1992. |
| Keywords: |
adult; cancer chemotherapy; clinical article; hydroxyurea; neutropenia; dose response; drug megadose; phase 2 clinical trial; bone marrow; bone marrow suppression; cytogenetics; chronic myeloid leukemia; time factors; fever; pilot projects; remission induction; neutrophils; leukocyte count; administration, oral; metaphase; granulocytopenia; oral drug administration; middle age; chronic leukemia; drug evaluation; philadelphia chromosome; leukemia, myeloid, chronic; leukemia, myeloid, philadelphia-positive; human; male; female; priority journal; article
|
