Treatment of Philadelphia chromosome positive (Ph +) chronic myelogenous leukemia in blast crisis and Ph + acute leukemia with high dose cytosine arabinoside (HDARAC) Journal Article

  

Authors:	Kempin, S.; Arlin, Z.; Berman, E.; Gee, T.; Mertelsmann, R.; Andreeff, M.; Kolitz, J.; Jhanwar, S.; Myers, J.; Clarkson, B.
Article Title:	Treatment of Philadelphia chromosome positive (Ph +) chronic myelogenous leukemia in blast crisis and Ph + acute leukemia with high dose cytosine arabinoside (HDARAC)
Abstract:	High dose cytosine arabinoside (HDARAC) was administered to eleven patients in the blastic phase of Philadelphia (Ph) chromosome positive chronic myelogenous leukemia (CML). Four patients presented in blastic phase and in seven patients blastic transformation had evolved from a previous chronic phase. All patients had been heavily pretreated with chronic phase drugs (hydroxyurea, myleran) or a protocol designed to treat the chronic phase (L-5 protocol) and with blastic phase regimens (anthracycline/araC combination or vincristine/prednisone). One of 11 patients achieved a complete remission (365 + days) and two patients achieved a partial response. No cytogenetic remissions were observed. The other patients were considered treatment failures with 3/8 surviving less than one month after therapy. Blasts were, at least temporarily, eliminated in all patients receiving at least 7 doses of HDARAC, although repopulation was rapid. HDARAC may be satisfactory therapy for accelerated phase CML but is minimally active in blastic phase CML. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords:	adult; clinical article; leukemia; busulfan; hydroxyurea; doxorubicin; cytarabine; melphalan; vincristine; cml; chronic myeloid leukemia; prednisolone; acute leukemia; daunorubicin; drug dose; anthracycline; tioguanine; philadelphia 1 chromosome; philadelphia chromosome; blast crisis; human; male; female; article
Journal Title:	Leukemia and Lymphoma
Volume:	4
Issue:	2
ISSN:	1042-8194
Publisher:	Taylor & Francis Group
Date Published:	1991-01-01
Start Page:	111
End Page:	116
Language:	English
DOI:	10.3109/10428199109068053
PROVIDER:	scopus
PUBMED:	27462940
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025906197&doi=10.3109%2f10428199109068053&partnerID=40&md5=4f4a6ffc3c1d12de9b9ea08a2348d1c9
Notes:	Source: Scopus

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