Treatment of blastic transformation of chronic myelogenous leukemia with mitoxantrone Journal Article

  

Authors:	Arlin, Z. A.; Berman, E.; Jhanwar, S.; Gams, R.; Schoch, I.; Dukart, G.
Article Title:	Treatment of blastic transformation of chronic myelogenous leukemia with mitoxantrone
Abstract:	Twenty-four patients with blastic-phase chronic myelogenous leukemia (CML) were treated with mitoxantrone. The patients included 19 whose cells were Philadelphia chromosome (Ph1+) and 5 who were either Ph1- or in whom cytogenetics were not available. Six of the 19 whose cells were Ph1+ responded and one of those who were Ph1- responded. The patients were further characterized into lymphoid or nonlymphoid on the basis of terminal deoxynucleotidyl transferase or morphology. Two of the patients with lymphoid transformation and 3 of those with nonlymphoid transformation responded. In 3 patients post-treatment cytogenetic evaluation revealed the presence of Ph1- metaphases. We conclude that mitoxantrone has modest activity in blCML and that the cytogenetic responses suggest the possibility of greater efficacy in chronic-phase CML. © 1986 Springer-Verlag.
Keywords:	adult; cancer chemotherapy; clinical article; aged; middle aged; drug efficacy; chemotherapy; heredity; cytogenetics; chronic myeloid leukemia; histology; drug mechanism; bone marrow biopsy; diagnosis; mitoxantrone; drug therapy; dna nucleotidylexotransferase; therapy; intravenous drug administration; philadelphia 1 chromosome; blast cell; philadelphia chromosome; anthraquinones; leukemia, myelocytic, acute; humans; human; male; female; priority journal; blast transformation; blood and hemopoietic system
Journal Title:	Cancer Chemotherapy and Pharmacology
Volume:	17
Issue:	2
ISSN:	0344-5704
Publisher:	Springer
Date Published:	1986-06-01
Start Page:	189
End Page:	190
Language:	English
DOI:	10.1007/bf00306753
PUBMED:	3459595
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022480208&doi=10.1007%2fBF00306753&partnerID=40&md5=b82b728012c7ce8362191a79f08d19bf
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus

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