Molecular pathology and molecular pharmacology of osteosarcoma Journal Article
| Authors: | Ladanyi, M.; Gorlick, R. |
| Article Title: | Molecular pathology and molecular pharmacology of osteosarcoma |
| Abstract: | Abnormalities of many tumor suppressor genes and oncogenes have been described in osteosarcoma, but separating early or primary from secondary or late genetic lesions has been difficult. Among early lesions, inactivation of both the P53 and RB pathways appears to be a central and perhaps necessary event in osteosarcomagenesis. We propose a working model for the molecular pathology of osteosarcoma and we review the numerous published studies examining the association of various molecular features with either advanced presentation, poor chemotherapy response or decreased patient survival. |
| Keywords: | osteosarcoma; cancer chemotherapy; cisplatin; doxorubicin; methotrexate; protein p16; gene amplification; gene expression; retinoblastoma; protein p53; ifosfamide; molecular cloning; tumor suppressor gene; molecular biology; cyclin d1; genetic code; oncogene myc; multidrug resistance; gene structure; oncogene neu; chromosome banding pattern; prognosis; human; priority journal; article; retinoblastoma (rb); oncogene c fos; cyclin dependent kinase (cdk) |
| Journal Title: | Pediatric Pathology and Molecular Medicine |
| Volume: | 19 |
| Issue: | 5 |
| ISSN: | 1522-7952 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2000-01-01 |
| Start Page: | 391 |
| End Page: | 413 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1080/15513810009168647 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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