Molecular imaging of sarcomas with FDG PET Review
| Authors: | Mendoza, H.; Nosov, A.; Pandit-Taskar, N. |
| Review Title: | Molecular imaging of sarcomas with FDG PET |
| Abstract: | Sarcoma comprises a heterogenous entity of musculoskeletal malignancies arising from a mesenchymal origin. The diagnosis and management of pediatric sarcoma requires a multidisciplinary approach and the use of various imaging modalities including CT, MRI and FDG PET scans. FDG PET/CT (FDG PET), as a metabolic imaging, complements and provides superior diagnostic information as against other imaging modalities alone. Advantages of FDG PET in differentiating malignant sarcomatous lesions from benign lesions, and value in staging and restaging have been noted in several studies. The use of FDG PET in clinical management has increased over the years. The data on prognostication of outcomes or predicting responders to therapy with FDG PET in patients with sarcoma is somewhat limited. This review will focus on the pearls and pitfalls of FDG PET and role of FDG PET in initial extent of disease assessment, treatment response, and surveillance imaging pertaining to osteosarcoma, chondrosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma. We also discuss the limitations and unmet needs of FDG PET in the management of patients with sarcoma. © 2022, The Author(s), under exclusive licence to International Skeletal Society (ISS). |
| Keywords: | osteosarcoma; child; bone neoplasms; bone tumor; cancer staging; positron emission tomography; neoplasm staging; radiopharmaceuticals; pathology; molecular imaging; diagnostic imaging; sarcoma; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; rhabdomyosarcoma; pet; soft tissue neoplasms; soft tissue tumor; fdg; procedures; humans; human; positron emission tomography-computed tomography; positron emission tomography computed tomography; ewing’s |
| Journal Title: | Skeletal Radiology |
| Volume: | 52 |
| Issue: | 3 |
| ISSN: | 0364-2348 |
| Publisher: | Springer |
| Date Published: | 2023-03-01 |
| Start Page: | 461 |
| End Page: | 475 |
| Language: | English |
| DOI: | 10.1007/s00256-022-04182-7 |
| PUBMED: | 36173459 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record only. Corresponding author is MSK author Neeta Pandit-Taskar -- Export Date: 1 February 2023 -- Source: Scopus |
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