The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein Journal Article
| Authors: | Fellows, J.; Erdjument-Bromage, H.; Tempst, P.; Svejstrup, J. Q. |
| Article Title: | The Elp2 subunit of elongator and elongating RNA polymerase II holoenzyme is a WD40 repeat protein |
| Abstract: | A novel yeast gene, ELP2, is shown to encode the 90-kDa subunit of the Elongator complex and elongating RNA polymerase II holoenzyme. ELP2 encodes a protein with eight WD40 repeats, and cells lacking the gene display typical elp phenotypes, such as temperature and salt sensitivity. Generally, different combinations of double and triple ELP gene deletions cause the same phenotypes as single ELP1, ELP2, or ELP3 deletion, providing genetic evidence that the ELP gene products work together in a complex. |
| Keywords: | controlled study; gene sequence; gene deletion; nonhuman; protein analysis; phenotype; gene expression; protein binding; blotting, western; amino acid sequence; molecular sequence data; sequence homology, amino acid; gene disruption; sequence homology; enzyme subunit; genetic code; rna polymerase ii; mutagenesis; protein derivative; holoenzyme; repetitive sequences, amino acid; holoenzymes; priority journal; article |
| Journal Title: | Journal of Biological Chemistry |
| Volume: | 275 |
| Issue: | 17 |
| ISSN: | 0021-9258 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Date Published: | 2000-04-28 |
| Start Page: | 12896 |
| End Page: | 12899 |
| Language: | English |
| DOI: | 10.1074/jbc.275.17.12896 |
| PUBMED: | 10777588 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
