Expression of cancer-testis antigens in lung cancer: Definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9 Journal Article

  


Authors: Scanlan, M. J.; Altorki, N. K.; Gure, A. O.; Williamson, B.; Jungbluth, A.; Chen, Y. T.; Old, L. J.
Article Title: Expression of cancer-testis antigens in lung cancer: Definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9
Abstract: In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 family of transcriptional regulators, is also expressed in cancer. Standard RT-PCR expression analysis detected BRDT transcripts in 12 of 47 cases of non-small cell lung cancer and single cases of both squamous cell carcinoma of the head and neck (1/12) and esophagus (1/12) but not in melanoma or in cancers of the colon, breast, kidney and bladder. Typing of 33 non-small cell lung cancers for coexpression of a panel of CT antigens revealed a high incidence (60%) of MAGE-3 mRNA expression, followed by MAGE-1 (36%), CT7/MAGE-C1 (30%), CT10 (30%), SSX4 (23%), BRDT (21%), NY-ESO-1 (21%) and HOM-MEL-40/SSX2 (15%). The coexpression pattern of these antigens provides a foundation for developing a polyvalent lung cancer vaccine. (C) 2000 Elsevier Science Ireland Ltd.
Keywords: human tissue; human cell; antigen expression; cancer immunotherapy; reverse transcription polymerase chain reaction; gene expression; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; cancer cell culture; tumor cells, cultured; tumor antigen; nuclear proteins; antigens, neoplasm; cancer vaccine; cancer vaccines; messenger rna; rna, messenger; cancer testis antigen; testis; complementary dna; bromodomain; humans; human; male; priority journal; article; brdt; ring3
Journal Title: Cancer Letters
Volume: 150
Issue: 2
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 2000-03-31
Start Page: 155
End Page: 164
Language: English
DOI: 10.1016/s0304-3835(99)00385-7
PUBMED: 10704737
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034003319&partnerID=40&md5=d34a4a7a33c1d262759ac1c38e522c13
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Matthew J Scanlan
    49 Scanlan
  2. Ali O Gure
    29 Gure
  3. Achim Jungbluth
    455 Jungbluth
  4. Lloyd J Old
    593 Old
  5. Barbara Williamson
    24 Williamson
  6. Yao-Tseng Chen
    83 Chen
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