Bioluminescence tomography with ct/mri co-registration Conference Paper
| Authors: | Klose, A. D.; Beattie, B. J. |
| Title: | Bioluminescence tomography with ct/mri co-registration |
| Conference Title: | 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine |
| Abstract: | We present a three-dimensional (3D) bioluminescence image reconstruction method with MRI and CT co-registration for small animal molecular imaging. The multi-spectral light intensity distribution of an optical luciferase-luciferin reporter system is measured at the tissue surface of a small animal for the purpose of 3D image reconstruction. The reporter probe distribution inside tissue is calculated with a linear matrix inversion method and a light propagation model based on the simplified spherical harmonics equations. The animal's surface geometry and anatomy is determined from co-registered CT and MR images in order to locate the reconstructed source distribution relative to the animal's anatomy. We present in vivo bioluminescence reconstruction results that demonstrate the performance of our co-registration method. ©2009 IEEE. |
| Keywords: | three dimensional; animals; computerized tomography; in-vivo; bioluminescence; 3d image reconstruction; bioluminescence tomography; coregistration; image reconstruction methods; light intensity distribution; linear matrix; mr images; multi-spectral; reporter systems; small animal; source distribution; spherical harmonics; surface geometries; three-dimensional (3d); tissue surface; harmonic analysis; image reconstruction; phosphorescence; repair |
| Journal Title | IEEE Engineering in Medicine and Biology Society. Conference Proceedings |
| Conference Dates: | 2009 Sept 3-6 |
| Conference Location: | Minneapolis, MN |
| ISBN: | 1557-170X |
| Publisher: | IEEE |
| Date Published: | 2009-11-13 |
| Start Page: | 6327 |
| End Page: | 6330 |
| Language: | English |
| DOI: | 10.1109/IEMBS.2009.5333170 |
| PROVIDER: | scopus |
| PUBMED: | 19964154 |
| DOI/URL: | |
| Notes: | --- - "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009" - "Export Date: 30 November 2010" - "Art. No.: 5333170" - "Source: Scopus" |
