The 2015 World Health Organization Classification of tumors of the thymus: Continuity and changes Journal Article
| Authors: | Marx, A.; Chan, J. K. C.; Coindre, J. M.; Detterbeck, F.; Girard, N.; Harris, N. L.; Jaffe, E. S.; Kurrer, M. O.; Marom, E. M.; Moreira, A. L.; Mukai, K.; Orazi, A.; Ströbel, P. |
| Article Title: | The 2015 World Health Organization Classification of tumors of the thymus: Continuity and changes |
| Abstract: | This overview of the 4th edition of the World Health Organization (WHO) Classification of thymic tumors has two aims. First, to comprehensively list the established and new tumor entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft-tissue tumors of the thymus and mediastinum; second, to highlight major differences in the new WHO Classification that result from the progress that has been made since the 3rd edition in 2004 at immunohistochemical, genetic and conceptual levels. Refined diagnostic criteria for type A, AB, B1-B3 thymomas and thymic squamous cell carcinoma are given, and it is hoped that these criteria will improve the reproducibility of the classification and its clinical relevance. The clinical perspective of the classification has been strengthened by involving experts from radiology, thoracic surgery, and oncology; by incorporating state-of-theart positron emission tomography/computed tomography images; and by depicting prototypic cytological specimens. This makes the thymus section of the new WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart a valuable tool for pathologists, cytologists, and clinicians alike. The impact of the new WHO Classification on therapeutic decisions is exemplified in this overview for thymic epithelial tumors and mediastinal lymphomas, and future perspectives and challenges are discussed. © 2015 by the International Association for the Study of Lung Cancer. |
| Keywords: | immunohistochemistry; review; positron emission tomography; staging; cancer diagnosis; undifferentiated carcinoma; adenocarcinoma; cytology; stem cell factor receptor; metastasis; classification; pathology; angiosarcoma; histology; acute lymphoblastic leukemia; hodgkin disease; sarcoma; b cell lymphoma; cd20 antigen; thymus; neuroblastoma; lymphoma; computer assisted emission tomography; sarcomatoid carcinoma; cytokeratin 20; teratoma; carcinoid; world health organization; protein p63; adenosquamous carcinoma; large cell lymphoma; lymphatic leukemia; clear cell carcinoma; cytokeratin 19; cancer classification; synovial sarcoma; thymoma; mediastinum; cd5 antigen; germ cell tumor; mediastinum tumor; marginal zone lymphoma; ganglioneuroma; thymic carcinoma; choriocarcinoma; embryonal carcinoma; seminoma; yolk sac tumor; thymus cancer; hemangioma; liposarcoma; computed tomography; hodgkin lymphoma; primary mediastinal large b-cell lymphoma; classical hodgkin lymphoma; granulocytic sarcoma; genetic; neuroendocrine; protein p40; lipoma; lymphangioma; mediastinum cancer; lymphoblastoma; international thymic malignancy interest group; immunohistology; mediastinal; human; priority journal; dendritic cell tumor; nut carcinoma; atypical type a thymoma; combined large-cell neuroendocrine carcinoma; combined thymic carcinoma; ectopic tumor; grey zone lymphoma; gtf2i; dendritic cell sarcoma; thymus adenocarcinoma; thymus basaloid carcinoma; thymus carcinoid; thymus squamous cell carcinoma |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 10 |
| Issue: | 10 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-10-01 |
| Start Page: | 1383 |
| End Page: | 1395 |
| Language: | English |
| DOI: | 10.1097/jto.0000000000000654 |
| PROVIDER: | scopus |
| PMCID: | PMC4581965 |
| PUBMED: | 26295375 |
| DOI/URL: | |
| Notes: | Export Date: 2 November 2015 -- Source: Scopus |
