Thymic carcinomas - A concise multidisciplinary update on recent developments from the Thymic Carcinoma Working Group of the International Thymic Malignancy Interest Group Review
| Authors: | Roden, A. C.; Ahmad, U.; Cardillo, G.; Girard, N.; Jain, D.; Marom, E. M.; Marx, A.; Moreira, A. L.; Nicholson, A. G.; Rajan, A.; Shepherd, A. F.; Simone, C. B. 2nd; Strange, C. D.; Szolkowska, M.; Truong, M. T.; Rimner, A. |
| Review Title: | Thymic carcinomas - A concise multidisciplinary update on recent developments from the Thymic Carcinoma Working Group of the International Thymic Malignancy Interest Group |
| Abstract: | Thymic carcinomas are rare malignancies that in general arise in the prevascular (anterior) mediastinum. These tumors are usually invasive, often present at advanced stages, and typically behave aggressively. Studies are hampered by the paucity of these tumors, the large variety of carcinoma subtypes, and the lack of unique morphologic and immunophenotypic features. Despite these challenges, advances in diagnostic imaging, surgical approaches, systemic therapies, and radiation therapy techniques have been made. The WHO classification of thymic epithelial tumors has been updated in 2021, and the eighth tumor nodal metastasis staging by the American Joint Committee on Cancer/Union for International Cancer Control included thymic carcinomas in 2017. Molecular alterations that provide more insight into the pathogenesis of these tumors and that potentially permit use of novel targeted therapies are increasingly being identified. New approaches to radiation therapy, chemotherapy, and immunotherapy are under evaluation. International societies, including the International Thymic Malignancy Interest Group, European Society of Thoracic Surgeons, and Japanese, Chinese, and Korean thymic associations, have been critical in organizing and conducting multi-institutional clinical studies. Herein, we review contemporary multidisciplinary perspectives in diagnosis and management of thymic carcinoma. © 2022 International Association for the Study of Lung Cancer |
| Keywords: | cancer staging; neoplasm staging; neoplasm; lung neoplasms; pathology; lung tumor; thymoma; thymic carcinoma; thymus neoplasms; neoplasms, glandular and epithelial; international thymic malignancy interest group; public opinion; who; tnm staging; humans; human; itmig |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 17 |
| Issue: | 5 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-05-01 |
| Start Page: | 637 |
| End Page: | 650 |
| Language: | English |
| DOI: | 10.1016/j.jtho.2022.01.021 |
| PUBMED: | 35227908 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2022 -- Source: Scopus |
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