ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: Refined definitions, histological criteria, and reporting Journal Article

  

Authors:	Marx, A.; Ströbel, P.; Badve, S. S.; Chalabreysse, L.; Chan, J. K. C.; Chen, G.; De Leval, L.; Detterbeck, F.; Girard, N.; Huang, J.; Kurrer, M. O.; Lauriola, L.; Marino, M.; Matsuno, Y.; Molina, T. J.; Mukai, K.; Nicholson, A. G.; Nonaka, D.; Rieker, R.; Rosai, J.; Ruffini, E.; Travis, W. D.
Article Title:	ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: Refined definitions, histological criteria, and reporting
Abstract:	Introduction: The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies. Methods: To overcome this problem, hematoxylin-eosin-stained and immunohistochemically processed sections of prototypic, "borderland," and "combined" thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group. Results: Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. "Atypical type A thymoma" is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed. Conclusion: These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.
Keywords:	neoplasms; thymoma; thymic carcinoma; expression; t-cells; epithelial tumors; criteria; myasthenia-gravis; diagnostic; histological classification; clinicopathological correlation; evidence-based pathology; micronodular thymoma; a thymomas; b-cell hyperplasia
Journal Title:	Journal of Thoracic Oncology
Volume:	9
Issue:	5
ISSN:	1556-0864
Publisher:	Elsevier Inc.
Date Published:	2014-05-01
Start Page:	596
End Page:	611
Language:	English
ACCESSION:	WOS:000334627500005
DOI:	10.1097/jto.0000000000000154
PROVIDER:	wos
PUBMED:	24722150
Notes:	Article -- Source: Wos

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