Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations Journal Article


Authors: Bassig, B. A.; Cerhan, J. R.; Au, W. Y.; Kim, H. N.; Sangrajrang, S.; Hu, W.; Tse, J.; Berndt, S.; Zheng, T.; Zhang, H.; Pornsopone, P.; Lee, J. J.; Kim, H. J.; Skibola, C. F.; Vijai, J.; Burdette, L.; Yeager, M.; Brennan, P.; Shin, M. H.; Liang, R.; Chanock, S.; Lan, Q.; Rothman, N.
Article Title: Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations
Abstract: Objectives: Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL) and is the most common NHL subtype diagnosed worldwide. The first large-scale genome-wide association study (GWAS) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNPs that achieved genome-wide significance, and two SNPs that showed a suggestive association with DLBCL risk. Methods: To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand. Results: Three of the five genome-wide significant SNPs from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS, EXOC2 rs116446171, which achieved genome-wide significance in our data (per allele OR = 2.04, 95% CI = 1.63-2.56; ptrend = 3.9 × 10-10). Additionally, we observed a significant association with PVT1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19-1.52; ptrend = 2.1 × 10-6), which was the second strongest finding in the GWAS, and with HLA-B rs2523607 (per allele OR = 3.05, 95% CI = 1.32-7.05; ptrend = 0.009). Conclusions: Our study, which provides the first evaluation in Eastern Asians of SNPs definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations. © 2015 John Wiley & Sons A/S.
Keywords: lymphoma; diffuse large b-cell lymphoma; eastern asians; genetic susceptibility to dlbcl
Journal Title: European Journal of Haematology
Volume: 95
Issue: 5
ISSN: 0902-4441
Publisher: John Wiley & Sons  
Date Published: 2015-11-01
Start Page: 442
End Page: 448
Language: English
DOI: 10.1111/ejh.12513
PROVIDER: scopus
PUBMED: 25611436
DOI/URL:
Notes: Export Date: 2 November 2015 -- Source: Scopus
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MSK Authors
  1. Vijai Joseph
    117 Joseph