Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma Journal Article
| Authors: | Bernatsky, S.; Garcia, H. A. V.; Spinelli, J. J.; Gaffney, P.; Smedby, K. E.; Ramsey-Goldman, R.; Wang, S. S.; Adami, H. O.; Albanes, D.; Angelucci, E.; Ansell, S. M.; Asmann, Y. W.; Becker, N.; Benavente, Y.; Berndt, S. I.; Bertrand, K. A.; Birmann, B. M.; Boeing, H.; Boffetta, P.; Bracci, P. M.; Brennan, P.; Brooks-Wilson, A. R.; Cerhan, J. R.; Chanock, S. J.; Clavel, J.; Conde, L.; Cotenbader, K. H.; Cox, D. G.; Cozen, W.; Crouch, S.; De Roos, A. J.; de Sanjose, S.; Di Lollo, S.; Diver, W. R.; Dogan, A.; Foretova, L.; Ghesquieres, H.; Giles, G. G.; Glimelius, B.; Habermann, T. M.; Haioun, C.; Hartge, P.; Hjalgrim, H.; Holford, T. R.; Holly, E. A.; Jackson, R. D.; Kaaks, R.; Kane, E.; Kelly, R. S.; Klein, R. J.; Kraft, P.; Kricker, A.; Lan, Q.; Lawrence, C.; Liebow, M.; Lightfoot, T.; Link, B. K.; Maynadie, M.; McKay, J.; Melbye, M.; Molina, T. J.; Monnereau, A.; Morton, L. M.; Nieters, A.; North, K. E.; Novak, A. J.; Offit, K.; Purdue, M. P.; Rais, M.; Riby, J.; Roman, E.; Rothman, N.; Salles, G.; Severi, G.; Severson, R. K.; Skibola, C. F.; Slager, S. L.; Smith, A.; Smith, M. T.; Southey, M. C.; Staines, A.; Teras, L. R.; Thompson, C. A.; Tilly, H.; Tinker, L. F.; Tjonneland, A.; Turner, J.; Vajdic, C. M.; Vermeulen, R. C. H.; Vijai, J.; Vineis, P.; Virtamo, J.; Wang, Z.; Weinstein, S.; Witzig, T. E.; Zelenetz, A.; Zeleniuch-Jacquotte, A.; Zhang, Y.; Zheng, T.; Zucca, M.; Clarke, A. E. |
| Article Title: | Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma |
| Abstract: | Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE. |
| Keywords: | cohort; consortium; hodgkin-lymphoma; erythematosus; cancer; systemic-lupus; subtypes project |
| Journal Title: | Lupus Science & Medicine |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 2053-8790 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 2017-01-01 |
| Start Page: | e000187 |
| Language: | English |
| ACCESSION: | WOS:000447607600007 |
| DOI: | 10.1136/lupus-2016-000187 |
| PROVIDER: | wos |
| PMCID: | PMC5715504 |
| PUBMED: | 29214033 |
| Notes: | Vijai Joseph's first and last names are reversed on the original publication -- Article -- UNSP e000187 -- Source: Wos |
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