Genetically determined height and risk of non-Hodgkin lymphoma Journal Article

   


Authors: Moore, A.; Kane, E.; Wang, Z.; Panagiotou, O. A.; Teras, L. R.; Monnereau, A.; Doo, N. W.; Machiela, M. J.; Skibola, C. F.; Slager, S. L.; Salles, G.; Camp, N. J.; Bracci, P. M.; Nieters, A.; Vermeulen, R. C. H.; Vijai, J.; Smedby, K. E.; Zhang, Y.; Vajdic, C. M.; Cozen, W.; Spinelli, J. J.; Hjalgrim, H.; Giles, G. G.; Link, B. K.; Clavel, J.; Arslan, A. A.; Purdue, M. P.; Tinker, L. F.; Albanes, D.; Ferri, G. M.; Habermann, T. M.; Adami, H. O.; Becker, N.; Benavente, Y.; Bisanzi, S.; Boffetta, P.; Brennan, P.; Brooks-Wilson, A. R.; Canzian, F.; Conde, L.; Cox, D. G.; Curtin, K.; Foretova, L.; Gapstur, S. M.; Ghesquières, H.; Glenn, M.; Glimelius, B.; Jackson, R. D.; Lan, Q.; Liebow, M.; Maynadie, M.; McKay, J.; Melbye, M.; Miligi, L.; Milne, R. L.; Molina, T. J.; Morton, L. M.; North, K. E.; Offit, K.; Padoan, M.; Patel, A. V.; Piro, S.; Ravichandran, V.; Riboli, E.; de Sanjose, S.; Severson, R. K.; Southey, M. C.; Staines, A.; Stewart, C.; Travis, R. C.; Weiderpass, E.; Weinstein, S.; Zheng, T.; Chanock, S. J.; Chatterjee, N.; Rothman, N.; Birmann, B. M.; Cerhan, J. R.; Berndt, S. I.
Article Title: Genetically determined height and risk of non-Hodgkin lymphoma
Abstract: Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Keywords: genetics; follicular lymphoma; marginal zone lymphoma; diffuse large b-cell lymphoma; non-hodgkin lymphoma; chronic lymphocytic leukemia; height; polygenic risk score
Journal Title: Frontiers in Oncology
Volume: 9
ISSN: 2234-943X
Publisher: Frontiers Media S.A.  
Date Published: 2020-01-28
Start Page: 1539
Language: English
DOI: 10.3389/fonc.2019.01539
PROVIDER: scopus
PMCID: PMC6999122
PUBMED: 32064237
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079502127&doi=10.3389%2ffonc.2019.01539&partnerID=40&md5=7623ec625ce73bef6e7b89d062debd40
Notes: Article -- Export Date: 2 March 2020 -- Source: Scopus
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MSK Authors
  1. Kenneth Offit
    791 Offit
  2. Vijai Joseph
    213 Joseph
  3. Vignesh Ravichandran
    38 Ravichandran
  4. Carolyn R Stewart
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