Immunological synapse formation: Cell polarity during T cell–APC interaction Book Section
| Authors: | Liu, X.; Huse, M. |
| Editor: | Ebnet, K. |
| Article/Chapter Title: | Immunological synapse formation: Cell polarity during T cell–APC interaction |
| Abstract: | Intercellular communication is essential for coordinating a successful immune response. The immunological synapse provides a platform for such communication by coupling activated lymphocytes specifically to their target cells. The formation of an IS in T cells is triggered by stimulation of the T cell antigen receptor and depends on the rapid and polarized remodeling of the cytoskeleton. This dramatic change in cell polarity is required to achieve optimal T cell activation and function. In this chapter, we will discuss the structure of the IS, how it forms, and how it contributes to T cell function during immune responses. © Springer International Publishing Switzerland 2015. |
| Keywords: | actin; cell polarity; centrosome; immunological synapse; t cell |
| Book Title: | Cell Polarity 1: Biological Role and Basic Mechanisms |
| ISBN: | 978-3-319-14462-7 |
| Publisher: | Springer |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2015-01-01 |
| Start Page: | 247 |
| End Page: | 275 |
| Language: | English |
| DOI: | 10.1007/978-3-319-14463-4_11 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 11 -- Export Date: 2 November 2015 -- Source: Scopus |
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