Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse Journal Article
| Authors: | Le Floc'h, A.; Huse, M. |
| Article Title: | Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse |
| Abstract: | Transient,specialized cell-cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function. |
| Keywords: | signal transduction; unclassified drug; nonhuman; protein function; t cells; t lymphocyte; actin; cytotoxicity; enzyme activation; phosphatidylinositol 3 kinase; t lymphocyte receptor; protein transport; cell polarity; f actin; microtubule; cell interaction; cell adhesion; cytoskeleton; integrin; rho guanine nucleotide binding protein; antigen presenting cell; depolymerization; lymphocyte function; protein cdc42; rac protein; protein modification; regulator protein; centrosome; immunological synapse; t cell receptor; wiskott aldrich syndrome protein; actin filament; docking protein; synaptogenesis; human; article; nucleation promoting factor; protein dock2; rho guanine nucleotide exchange factor |
| Journal Title: | Cellular and Molecular Life Sciences |
| Volume: | 72 |
| Issue: | 3 |
| ISSN: | 1420-682X |
| Publisher: | Springer |
| Date Published: | 2015-02-01 |
| Start Page: | 537 |
| End Page: | 556 |
| Language: | English |
| DOI: | 10.1007/s00018-014-1760-7 |
| PROVIDER: | scopus |
| PMCID: | PMC4294954 |
| PUBMED: | 25355055 |
| DOI/URL: | |
| Notes: | Export Date: 2 March 2015 -- Source: Scopus |
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