Mechanical forces in the immune system Journal Article
| Author: | Huse, M. |
| Article Title: | Mechanical forces in the immune system |
| Abstract: | Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This structural plasticity, which facilitates their migration and communicative function, also enables them to exert a substantial amount of mechanical force against the extracellular matrix and the surfaces of interacting cells. In recent years, it has become increasingly clear that these forces have crucial roles in immune cell activation and subsequent effector responses. Here, I review our current understanding of how mechanical force regulates cell-surface receptor activation, cell migration, intracellular signalling and intercellular communication, highlighting the biological ramifications of these effects in various immune cell types. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Keywords: | review; animal; cytology; electron microscopy; metabolism; animals; cell function; immune system; cell motion; physiology; immunology; mammalian target of rapamycin; cell movement; cell interaction; cell activation; cell adhesion; cell communication; myosin ii; cytoskeleton; leukocyte; intercellular adhesion molecule 1; immunocompetent cell; intercellular adhesion molecule 2; cell surface receptor; intracellular signaling; mechanotransduction; leukocytes; atomic force microscopy; biomechanics; phospholipase d2; humans; human; priority journal; traction force microscopy; leukocyte rolling; biomechanical phenomena; mechanotransduction, cellular |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 17 |
| Issue: | 11 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-11-01 |
| Start Page: | 679 |
| End Page: | 690 |
| Language: | English |
| DOI: | 10.1038/nri.2017.74 |
| PUBMED: | 28757604 |
| PROVIDER: | scopus |
| PMCID: | PMC6312705 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 December 2017 -- Source: Scopus |
