Infertility and incident endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2) Journal Article


Authors: Yang, H. P.; Cook, L. S.; Weiderpass, E.; Adami, H. O.; Anderson, K. E.; Cai, H.; Cerhan, J. R.; Clendenen, T. V.; Felix, A. S.; Friedenreich, C. M.; Garcia-Closas, M.; Goodman, M. T.; Liang, X.; Lissowska, J.; Lu, L.; Magliocco, A. M.; McCann, S. E.; Moysich, K. B.; Olson, S. H.; Petruzella, S.; Pike, M. C.; Polidoro, S.; Ricceri, F.; Risch, H. A.; Sacerdote, C.; Setiawan, V. W.; Shu, X. O.; Spurdle, A. B.; Trabert, B.; Webb, P. M.; Wentzensen, N.; Xiang, Y. B.; Xu, Y.; Yu, H.; Zeleniuch-Jacquotte, A.; Brinton, L. A.
Article Title: Infertility and incident endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2)
Abstract: Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.Methods:We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).Results:Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI: 1.59-1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI: 1.13-1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.Conclusions:Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters. © 2015 Cancer Research UK. All rights reserved.
Keywords: adult; controlled study; aged; major clinical study; case control study; cancer risk; cancer incidence; endometrium cancer; cohort analysis; confidence interval; cancer registry; cancer epidemiology; logistic regression analysis; female infertility; nullipara; human; female; priority journal; article
Journal Title: British Journal of Cancer
Volume: 112
Issue: 5
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2015-03-03
Start Page: 925
End Page: 933
Language: English
DOI: 10.1038/bjc.2015.24
PROVIDER: scopus
PMCID: PMC4453954
PUBMED: 25688738
DOI/URL:
Notes: Export Date: 2 September 2015 -- Source: Scopus
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MSK Authors
  1. Malcolm Pike
    133 Pike
  2. Sara H Olson
    213 Olson
  3. Xiaolin Liang
    41 Liang
  4. Youming   Xu
    5 Xu