The prognostic impact of peripheral blood progenitor cell dose following high-dose therapy and autologous stem cell transplant for hematologic malignancies Journal Article

  


Authors: Sauter, C. S.; Giralt, S.
Article Title: The prognostic impact of peripheral blood progenitor cell dose following high-dose therapy and autologous stem cell transplant for hematologic malignancies
Abstract: High-dose chemotherapy (HDT) followed by autologous peripheral blood progenitor cell transplant (PBPCT) has become a standard intervention in certain clinical settings of hematologic malignancies, particularly multiple myeloma and relapsed/refractory lymphoma. While the minimal required PBPCs infused, as defined by number of CD34 + cells, has been relatively well delineated for adequate hematopoietic recovery post-HDT, optimal PBPC dose has not been clearly defined. This is particularly relevant in the context of retrospective data suggesting improved survival outcomes with increased PBPC doses. The potential confounding of these data as they relate to disease risk is discussed within this review. Additionally, other retrospective data have suggested that enhanced quantitative lymphocyte subset reconstitution post-HDT-PBPCT may confer progression-free and overall survival advantage. These reported series herein reviewed may inform discussion of future, prospective clinical trials with the intent of defining optimal autologous PBPC dose following HDT, especially as it may relate to metrics beyond hematopoietic recovery. © 2014 Informa UK, Ltd.
Keywords: autologous transplant; cell dose
Journal Title: Leukemia and Lymphoma
Volume: 56
Issue: 6
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2015-06-01
Start Page: 1619
End Page: 1625
Language: English
DOI: 10.3109/10428194.2014.970544
PROVIDER: scopus
PUBMED: 25284496
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84932144118&partnerID=40&md5=ffe5172082a72e79bcf0ace6e4c16ae9
Notes: Export Date: 3 August 2015 -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    1051 Giralt
  2. Craig Steven Sauter
    334 Sauter
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