High-dose chemotherapy and autologous stem cell transplant in older patients with lymphoma Journal Article
| Authors: | Lahoud, O. B.; Sauter, C. S.; Hamlin, P. A.; Dahi, P. B. |
| Article Title: | High-dose chemotherapy and autologous stem cell transplant in older patients with lymphoma |
| Abstract: | High-dose chemotherapy followed by autologous hematopoietic stem cell transplant (HDT/ASCT) can improve survival in patients with lymphoma. Limited experience is available on the safety and efficacy of HDT/ASCT in elderly patients. In this article, we review the published data on the role of HDT/ASCT in management of lymphoma in older patients. Based on available data, evaluation of comorbidities, functional status, and comprehensive geriatric assessment (CGA) will help identify those who can benefit most from this intervention. Prospective clinical trials focusing on HDT/ASCT in older patients with lymphoma are needed to establish optimal management protocols in this select population. © 2015, Springer Science+Business Media New York. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; aged; overall survival; drug tolerability; mortality; review; patient selection; disease free survival; cytarabine; progression free survival; mantle cell lymphoma; bone marrow; etoposide; blood toxicity; gastrointestinal symptom; clinical assessment; cyclophosphamide; melphalan; cell renewal; carmustine; nonhodgkin lymphoma; cardiotoxicity; lymphoma; comorbidity; stem cell mobilization; aging; lactate dehydrogenase; clinical effectiveness; age distribution; large cell lymphoma; high risk population; immunosuppressive treatment; elderly; follicular lymphoma; plerixafor; functional status; autologous hematopoietic stem cell transplantation; history of medicine; filgrastim; international prognostic index; cell; transplant; pegfilgrastim; rescue; hematopoietic; autologous; stem; comprehensive geriatric assessment; cancer prognosis; human; transplant related mortality; assessment of humans; hematopoietic cell transplantation comorbidity index; high dose chemotherapy |
| Journal Title: | Current Oncology Reports |
| Volume: | 17 |
| Issue: | 9 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2015-09-01 |
| Start Page: | 42 |
| Language: | English |
| DOI: | 10.1007/s11912-015-0465-x |
| PROVIDER: | scopus |
| PUBMED: | 26201264 |
| PMCID: | PMC5542393 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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