Double-strand breaks and tumorigenesis Journal Article
| Authors: | Pierce, A. J.; Stark, J. M.; Araujo, F. D.; Moynahan, M. E.; Berwick, M.; Jasin, M. |
| Article Title: | Double-strand breaks and tumorigenesis |
| Abstract: | The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways - homologous recombination and nonhomologous end-joining - with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link. |
| Keywords: | gene mutation; genetics; mutation; clinical trial; review; nonhuman; neoplasms; dna recombination; phenotype; animals; dna damage; gene; dna repair; disease association; carcinogenesis; dna; recombination, genetic; genes, brca1; genes, brca2; medical literature; chromosome disorder; genetic diseases, inborn; chromosome disorders; humans; human; priority journal |
| Journal Title: | Trends in Cell Biology |
| Volume: | 11 |
| Issue: | 11 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2001-11-01 |
| Start Page: | S52 |
| End Page: | S59 |
| Language: | English |
| DOI: | 10.1016/s0962-8924(01)02149-3 |
| PUBMED: | 11684443 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
