Double-strand breaks and tumorigenesis Journal Article


Authors: Pierce, A. J.; Stark, J. M.; Araujo, F. D.; Moynahan, M. E.; Berwick, M.; Jasin, M.
Article Title: Double-strand breaks and tumorigenesis
Abstract: The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways - homologous recombination and nonhomologous end-joining - with the development of human tumors. Although definitive proof has yet to be obtained, the current literature is highly suggestive of such a link.
Keywords: gene mutation; genetics; mutation; clinical trial; review; nonhuman; neoplasms; dna recombination; phenotype; animals; dna damage; gene; dna repair; disease association; carcinogenesis; dna; recombination, genetic; genes, brca1; genes, brca2; medical literature; chromosome disorder; genetic diseases, inborn; chromosome disorders; humans; human; priority journal
Journal Title: Trends in Cell Biology
Volume: 11
Issue: 11
ISSN: 0962-8924
Publisher: Elsevier Inc.  
Date Published: 2001-11-01
Start Page: S52
End Page: S59
Language: English
DOI: 10.1016/s0962-8924(01)02149-3
PUBMED: 11684443
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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MSK Authors
  1. Felipe Araujo
    2 Araujo
  2. Marianne Berwick
    116 Berwick
  3. Jeremy M Stark
    8 Stark
  4. Andrew J Pierce
    11 Pierce
  5. Maria Jasin
    210 Jasin