| Abstract: |
This review will discuss how STAT (Signal Transducers and Activators of Transcription) proteins, a group of transcription factors that transmit signals from the extracellular surface of cells to the nucleus, are involved in growth control. I will discuss the anatomy of a STAT protein, how it works as a transcription factor, the molecules that regulate its "activity", the phenotypes of mice that lack individual STAT proteins and their involvement in growth, differentiation, apoptosis, and transformation. Finally, a number of examples will be presented of how dysregulated STAT signaling may be involved in the pathogenesis of cancer. © 2001 John Wiley & Sons, Inc. |
| Keywords: |
dna binding protein; dna-binding proteins; review; mouse; animal; metabolism; animals; mice; cell division; stat1 protein; stat3 protein; apoptosis; cell differentiation; physiology; chemistry; transactivator protein; transactivation; stat3 transcription factor; protein structure, tertiary; trans-activators; stat5 protein; stat5 transcription factor; protein tertiary structure; stat3 protein, human; stat3 protein, mouse; trans-activation (genetics); stat4 protein; stat4 transcription factor; stat1 transcription factor; stat4 protein, mouse; milk proteins; stat6 protein; humans; human; stat2 protein; milk protein; stat1 protein, human; stat1 protein, mouse; stat2 protein, human; stat4 protein, human; stat6 protein, human; stat6 protein, mouse; stat2 transcription factor; stat6 transcription factor
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