“Skin cancer, polyphenols, and oxidative stress” or counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols Book Section
| Authors: | Philips, N.; Richardson, R.; Siomyk, H.; Bynum, D.; Gonzalez, S. |
| Editors: | Preedy, V. R.; Patel, V. B. |
| Article/Chapter Title: | “Skin cancer, polyphenols, and oxidative stress” or counteraction of oxidative stress, inflammation, signal transduction pathways, and extracellular matrix remodeling that mediate skin carcinogenesis by polyphenols |
| Abstract: | The characteristics of malignancy are cell growth and remodeling of the extracellular matrix for angiogenesis and metastasis. One of the major causes of skin cancer (melanoma and nonmelanoma) is the cellular accumulation reactive oxygen species (ROS), which outbalances the cellular antioxidant system, with intrinsic aging but more so with the exposure of skin to environmental pollutants and ultraviolet (UV) radiation. The ROS damage DNA, proteins, and lipids, and activate inflammatory cytokines that activate the signal transduction pathways of the mitogen-activated protein kinase (MAPK), nuclear factor-kappa beta (NF-kB)/p65, and JAK/STAT (Signal Transduction and Activation of Transcription) that, in turn activate factors such as activator-1 (AP-1) transcription factor. The activation of these pathways results in the increased expression of matrixmetalloproteinases (MMPs), Transforming Growth Factor-β (TGF-β), and Vascular Endothelial Growth Factor (VEGF), which collectively remodel the extracellular matrix (ECM) for tumor growth, angiogenesis, and metastasis. © 2021 Elsevier Inc. |
| Keywords: | transforming growth factor-β (tgf-β); vascular endothelial growth factor (vegf); extracellular matrix (ecm); reactive oxygen species (ros); stat (signal transduction and activation of transcription); ultraviolet (uv); matrixmetalloprotienases (mmp); mitogen-activated protein kinase (mapk); nanobiomaterials; nuclear factor-kappa beta (nf-kb) |
| Book Title: | Cancer: Oxidative Stress and Dietary Antioxidants. 2nd ed |
| ISBN: | 978-0-12-819547-5 |
| Publisher: | Academic Press |
| Publication Place: | London, United Kingdom |
| Date Published: | 2021-01-01 |
| Start Page: | 439 |
| End Page: | 450 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-819547-5.00039-0 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 39, part of "Section B: Antioxidants and cancer" -- Export Date: 1 April 2022 -- Source: Scopus |
