| Abstract: |
Many phytochemicals are endowed with photoprotective properties, that is, the capability to prevent the harmful effects of excessive exposure to ultraviolet (UV) light. These effects, most of them mediated by oxidative stress, include sunburn, immunosuppression photoaging, and skin cancer. A Polypodium leucotomos fern extract (Fernblock®) has shown cutaneous antioxidant properties after topical and/or oral administration. Fernblock inhibits the generation of reactive oxygen species (ROS), including superoxide anion and their release, which are both induced by UV light. It also prevents damage to the DNA, inhibits UV-induced AP1 and NF-αB, and protects the endogenous skin natural antioxidant enzymatic systems (i.e., CAT, GSH, and GSSR). At a cellular level, its photoprotective effects include a marked decrease of UV-mediated cellular apoptosis and necrosis and a profound inhibition of abnormal extracellular matrix remodeling. These molecular and cellular effects translate into long-term inhibition of photoaging and carcinogenesis. © 2014 Elsevier Inc. All rights reserved. |
