Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development Journal Article
| Author: | Bromberg, J. |
| Article Title: | Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development |
| Abstract: | STAT transcription factors were discovered 10 years ago as mediators of interferon-induced gene expression. They now form an important group, comprising seven members, that are activated by virtually every cytokine and growth factor. Their critical role in development and normal cell signaling has been largely determined through the analysis of transgenic mice lacking individual STAT genes. In addition, cell culture work has further delineated their importance in cellular transformation, apoptosis, differentiation and growth control. This review discusses the specific phenotypes of STAT-deficient animals with a focus on STAT5 and STAT3, as these two STAT molecules are required for normal breast development and involution, respectively, and may play an important role in breast carcinogenesis. |
| Keywords: | apoptosis; c-myc; involution; breast development; t-cells; cell-cycle progression; targeted disruption; constitutive activation; protein-tyrosine-phosphatase; gene-regulation; hematopoietic-cells; stat3 activation; mammary-gland; signal transducers; cancer; and activators of transcription; (stats) |
| Journal Title: | Breast Cancer Research |
| Volume: | 2 |
| Issue: | 2 |
| ISSN: | 1465-5411 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2000-01-28 |
| Start Page: | 86 |
| End Page: | 90 |
| Language: | English |
| ACCESSION: | WOS:000167335100004 |
| DOI: | 10.1186/bcr38 |
| PROVIDER: | wos |
| PMCID: | PMC139428 |
| PUBMED: | 11250696 |
| Notes: | Review -- Source: Wos |
